hannibalbigbang:

SIGNAL BOOST!
Are you a rad artist in the Hannibal fandom? Do you make amazing video edits that should be shared with the world? Can you create amazing mixtapes or insane graphics? 
Or maybe you’re a fanfic fan with a good eye for grammar?
The Hannibal Big Bang is currently looking for creative types to join us!
We’re currently in the process of signing up ARTISTS and BETA READERS until August 31. All you have to do is stop by, read the FAQ, and send us a message telling us you want to join! Artists will have an entire lovely month to create, so don’t worry about time crunches, there’s plenty of it.
Come join us and let’s flood the airwaves with awesome creations!

hannibalbigbang:

SIGNAL BOOST!

Are you a rad artist in the Hannibal fandom? Do you make amazing video edits that should be shared with the world? Can you create amazing mixtapes or insane graphics? 

Or maybe you’re a fanfic fan with a good eye for grammar?

The Hannibal Big Bang is currently looking for creative types to join us!

We’re currently in the process of signing up ARTISTS and BETA READERS until August 31. All you have to do is stop by, read the FAQ, and send us a message telling us you want to join! Artists will have an entire lovely month to create, so don’t worry about time crunches, there’s plenty of it.

Come join us and let’s flood the airwaves with awesome creations!

(via imaginehanniballecter)

i wanna be a beta reader

"

I think the saddest people always try their hardest to make people happy

because they know what it’s like to feel absolutely worthless

and they don’t want anyone else to feel like that.

"
-

Robin Williams (via skateeofmind)

S

(via disquiet—mind)

(via rucbarwhovian)

ineffable-hufflepuff:

misandryevans:

babymarkers:

the-chocolate-chip-pancake:

thatsnotwatyourmomsaid:

none pizza with left beef

It should be a rule of Tumblr to always reblog none pizza with left beef

ive missed you

#THIS IS MY FAVORITE FUCKING THING JUST THE BEEF#YOU COULD TELL THE POOR CHEF WAS JUST FUCKING#DISGUSTED#WHAT THE FUCK IS THIS#WHAT THE F U C K IS THIS#WHO THE FUCK ORDERS A#A /NONE/ PIZZA?? JUST BEEF ON THE LEFT???#FUCK IT#F U CK IT#JUST COOK THE FUCKING DOUGH#HERE LET ME THROW THIS FUCKING HANDFUL OF OBLONG BEEF CHUNKS AT YOUR NONE FUCKING PIZZA#FUCK YOU#FUCK YOU AND ALL YOU STAND FOR#LEFT FUCKING BEEF (via askscientistcarlos)

I love None Pizza with Left Beef.

ineffable-hufflepuff:

misandryevans:

babymarkers:

the-chocolate-chip-pancake:

thatsnotwatyourmomsaid:

none pizza with left beef

It should be a rule of Tumblr to always reblog none pizza with left beef

ive missed you

 (via askscientistcarlos)

I love None Pizza with Left Beef.

(Source: ollielephant, via what-are-frogs)

sometimes i randomly stop to laugh about this be like doing the dishes and just bust out laughing it's like a running joke in my house all you gotta say is none pizza with left beef

neurosciencestuff:

New study throws into question long-held belief about depression
New evidence puts into doubt the long-standing belief that a deficiency in serotonin — a chemical messenger in the brain — plays a central role in depression. In the journal ACS Chemical Neuroscience, scientists report that mice lacking the ability to make serotonin in their brains (and thus should have been “depressed” by conventional wisdom) did not show depression-like symptoms.
Donald Kuhn and colleagues at the John D. Dingell VA Medical Center and Wayne State University School of Medicine note that depression poses a major public health problem. More than 350 million people suffer from it, according to the World Health Organization, and it is the leading cause of disability across the globe. In the late 1980s, the now well-known antidepressant Prozac was introduced. The drug works mainly by increasing the amounts of one substance in the brain — serotonin. So scientists came to believe that boosting levels of the signaling molecule was the key to solving depression. Based on this idea, many other drugs to treat the condition entered the picture. But now researchers know that 60 to 70 percent of these patients continue to feel depressed, even while taking the drugs. Kuhn’s team set out to study what role, if any, serotonin played in the condition.
To do this, they developed “knockout” mice that lacked the ability to produce serotonin in their brains. The scientists ran a battery of behavioral tests. Interestingly, the mice were compulsive and extremely aggressive, but didn’t show signs of depression-like symptoms. Another surprising finding is that when put under stress, the knockout mice behaved in the same way most of the normal mice did. Also, a subset of the knockout mice responded therapeutically to antidepressant medications in a similar manner to the normal mice. These findings further suggest that serotonin is not a major player in the condition, and different factors must be involved. These results could dramatically alter how the search for new antidepressants moves forward in the future, the researchers conclude.

neurosciencestuff:

New study throws into question long-held belief about depression

New evidence puts into doubt the long-standing belief that a deficiency in serotonin — a chemical messenger in the brain — plays a central role in depression. In the journal ACS Chemical Neuroscience, scientists report that mice lacking the ability to make serotonin in their brains (and thus should have been “depressed” by conventional wisdom) did not show depression-like symptoms.

Donald Kuhn and colleagues at the John D. Dingell VA Medical Center and Wayne State University School of Medicine note that depression poses a major public health problem. More than 350 million people suffer from it, according to the World Health Organization, and it is the leading cause of disability across the globe. In the late 1980s, the now well-known antidepressant Prozac was introduced. The drug works mainly by increasing the amounts of one substance in the brain — serotonin. So scientists came to believe that boosting levels of the signaling molecule was the key to solving depression. Based on this idea, many other drugs to treat the condition entered the picture. But now researchers know that 60 to 70 percent of these patients continue to feel depressed, even while taking the drugs. Kuhn’s team set out to study what role, if any, serotonin played in the condition.

To do this, they developed “knockout” mice that lacked the ability to produce serotonin in their brains. The scientists ran a battery of behavioral tests. Interestingly, the mice were compulsive and extremely aggressive, but didn’t show signs of depression-like symptoms. Another surprising finding is that when put under stress, the knockout mice behaved in the same way most of the normal mice did. Also, a subset of the knockout mice responded therapeutically to antidepressant medications in a similar manner to the normal mice. These findings further suggest that serotonin is not a major player in the condition, and different factors must be involved. These results could dramatically alter how the search for new antidepressants moves forward in the future, the researchers conclude.

depression serotonin science

"Plaintiff Matthews was confronted by approximately eight Defendant John Doe police officers in military type uniforms who had their weapons trained upon him. Plaintiff immediately put his hands in the air whereupon he was shot multiple times with rubber bullets.

At that point, Plaintiff Matthews fell into a creek or sewer. Defendant John Doe officers pounced on him, slammed his face into the concrete, and pushed his head underwater to the point that he felt he was going to be drowned. Afterward, Defendant John Doe police officers continued to assault him and spray him with O.C. spray."
- Ferguson protesters are finally hitting police where it hurts … to the tune of $41.5 million  (via micdotcom)

(via spacious-infinity)

ferguson

"You arrived weighed down with gifts. You should depart empty handed."
- John Patrick Shanley (via psychotherapy)

geeksofdoom:

smitethepatriarchy:

feministingforchange:

rawr0609:

therawrchannel:

thinksquad:

A Democratic Missouri state senator representing parts of Ferguson who tweeted multiple times “fuck you,” at Missouri Gov. Jay Nixon defended her choice of words on Fox News Monday saying she did so because she was tear-gassed for three days.

“The reason why I used profane language is because he has allowed us to get tear-gassed for three days,” Sen. Maria Chappelle-Nadal said. “I am one of his senators in his party and he was at the state fair enjoying a country concert while we were getting teargassed and shot at. And yes, anyone who’s going to get teargassed deserves to say a few ‘F’ bombs here and there.”

“I represent my constituents, not Gov. Nixon,” the senator said. “He has been absent from the minority community his entire career and only comes before us when it is politically expedient for him. Or when he’s running for office, and because he has been outside of this community…let me tell you this, and this is important for your audience to know. He has still yet to come to ground zero. Yet to come to ground zero. He’s been in Florissant, he’s been in Normandy, but he has not spoken to the victims of the crisis we are dealing with and that is why I have called him a coward.”

http://www.buzzfeed.com/andrewkaczynski/missouri-state-senator-says-she-tweeted-fck-you-at-governor#32tdaru

real shit

run for president

Boost this story!!! 

This woman needs our support!!

Seriously fuck that guy.

Boost

(via what-are-frogs)